何永興,男,漢族人,現任蘭州大學生命科學院教授。
主要研究方向是農業微生物次生代謝物合成的調控機制和對環境的適應性機制。
中文名何永興
國籍中國
民族漢
學位/學歷博士
職業教師
職務蘭州大學生命科學院教授
人物經歷學習經歷2011/02-2013/02,加州大學伯克利分校,生物化學與分子生物學系(定量生物學研究所QB3),博士后;
2005/09-2010/12,中國科大,生化與分子生物系,博士;
2001/09-2005/07,中國科大,生命科學院,學士。
工作經歷2013/03-2020/12,蘭州大學生命科學學院,副教授;
2020/12-至今,?蘭州大學生命科學學院,教授。
主要成就科研項目國家自然科學基金委面上項目:吲哚調節熒光假單胞菌耐藥性及莫匹羅星合成的分子機制研究(31971422),執行時間:2020/01-2023/12;
國家自然科學基金委面上項目:毒素-抗毒素MqsRA調控熒光假單胞菌抗藥性的分子機制研究(31972319),執行時間:2020/01-2023/12;
國家自然科學基金委面上項目:植物根際促生菌Pudomonas-fluorescems?2P24感受與影響類黃酮的分子機制研究,執行時間:2018/01-2021/12;
國家自然科學基金委青年項目:熒光假單胞桿菌中的抗生素DAPG合成酶的晶體結構及其催化機理,2014/01-2016/12;
甘肅省自然科學基金面上項目:黃酮類物質對雄激素受體信號轉導的拮抗機制研究,2019年/01-2020/12;
國家自然科學基金委面上項目:2,4-DAPG及MAPG作為熒光假單胞菌信號分子的作用機制,執行時間:2020/01-2023/12?承擔經費:22萬。
榮譽表彰2019年甘肅醫學科技獎一等獎,排名5/9;
2019年甘肅省科技進步二等獎,排名7/10。
論文著作Song?Y*,?Zhang?SP*,?Luo?G,?Shen?Y,?Li?C,?Zhu?Y,?Huang?Q,?Mou?X,?Tang?X,?Liu?T,?Wu?S,?Tong?A,?He?YX#,?Bao?R#.?Type?II?Antitoxin?HigA?Is?a?Key?Virulence?Regulator?in?Pudomonas?aeruginosa.?ACS?Infect?Dis.?2021?Sep?23
Han?JT,?Zhu?Y,?Pan?DB,?Xue?HX,?Wang?S,?Peng?Y,?Liu?H#,?He?YX#,?Yao?X#.?Discovery?of?pentapeptide-inhibitor?hits?targeting?FKBP51?by?combining?computational?modeling?and?X-ray?crystallography.?Comput?Struct?Biotechnol?J.?2021?Jul?21;19:4079-4091
Zhang?SP,?Feng?HZ,?et?al.?Feng?HY#,?He?YX#?Proteomic?analysis?reveals?the?mechanism?of?different?environmental?stress?-induced?tolerance?of?Pudomonas?aeruginosa?PAO1?to?monochloramine?disinfection.?J?Hazard?Mater.?2021?Sep?5;417:126082.
Han?JT,?Li?DY,?Zhang?MY,?Yu?XQ,?Jia?XX,?Xu?H,?Yan?X,?Jia?WJ,?Niu?S,?Kempher?ML,?Tao?X,?He?YX#.?EmhR?is?an?indole-nsing?transcriptional?regulator?responsible?for?the?indole-induced?antibiotic?tolerance?in?Pudomonas?fluorescens.?Environ?Microbiol.?2021?Apr;23(4):2054-2069
Li?T*,?Song?Y*,?et?al.?He?YX,?Bao?R.?Molecular?Basis?of?the?Versatile?Regulatory?Mechanism?of?HtrA-Type?Protea?AlgW?from?Pudomonas?aeruginosa.?mBio.?2021?Feb?23;12(1):e03299-20.?
Song?Y,?Luo?G,?Zhu?Y,?Li?T,?Li?C,?He?L,?Zhao?N,?Zhao?C,?Yang?J,?Huang?Q,?Mu?X,?Tang?X,?Kang?M,?Wu?S,?He?YX#,?Bao?R#.?Pudomonas?aeruginosa?antitoxin?HigA?functions?as?a?diver?regulatory?factor?by?recognizing?specific?pudopalindromic?DNA?motifs.?Environ?Microbiol.?2021?Mar;23(3):1541-1558
Zhang?SP,?Feng?HZ,?Wang?Q,?Kempher?ML,?Quan?SW,?Tao?X,?Niu?S,?Wang?Y,?Feng?HY#,?He?YX#.?Bacterial?type?II?toxin-antitoxin?systems?acting?through?post-translational?modifications.?Comput?Struct?Biotechnol?J.?2020?Dec?11;19:86-93.?
Guo?DD*,?Luo?LM*?et?al.?He?YX#?The?regulator?PltZ?regulates?a?novel?antibiotic?efflux?pump?PltIJKNOP?of?Pudomonas?aeruginosa?ATCC?27853?in?respon?to?the?antimicrobial?2,4-diacetylphloroglucinol.?Front?Microbiol.?2020?Jul?8;11:1423
Yu?XQ*,?Yan?X*.?et?al.?He?YX#?Flavonoids?repress?production?of?antifungal?2,4-DAPG?but?potentially?facilitate?root?colonization?of?the?rhizobacterium?Pudomonas?fluorescens.?Environ?Microbiol.?2020?Dec;22(12):5073-5089
Zhang?SP,?Wang?Q,?Quan?SW,?Yu?XQ,?Wang?Y,?Guo?DD,?Peng?L,?Feng?HY#,?He?YX#?Type?II?toxin-antitoxin?system?in?bacteria:?activation,?function?and?mode?of?action.?Biophysical?Reports.?2020
Na?M,?Zhng?S,?Liu?J,?Ma?S,?Han?Y,?Wang?Y,?He?YX,?Chen?H,?Chen?X.?Determination?of?pathogenic?bacteria-Bacillus?anthrax?spores?in?environmental?samples?by?ratiometric?fluorescence?and?test?paper?bad?on?dual-emission?fluorescent?silicon?nanoparticles.?J?Hazard?Mater.?2020?Mar?15;386:121956
Zhang?ZY,?Bai?HH,?Guo?Z,?Li?HL,?He?YT,?Duan?XL,?Suo?ZW,?Yang?X,?He?YX,?Hu?XD.?mGluR5/ERK?signaling?regulated?the?phosphorylation?and?function?of?glycine?receptor?α1ins?subunit?in?spinal?dorsal?horn?of?mice.?PLoS?Biol.?2019?Aug?21;17(8)
Han?JT*,?Zhang?SP*,?Jia?WJ,?Zhang?Z,?Wang?Y,?He?YX#.?Discovery?and?structural?analysis?of?a?phloretin?hydrola?from?the?opportunistic?human?pathogen?Mycobacterium?abscessus.?FEBS?Journal.?2019?
Wang?Y*,?Zhang?SP*,?Zhang?MY,?Kempher?ML,?Guo?DD,?Han?JT,?Tao?X,?Wu?Y,?Zhang?LQ,?He?YX#.?The?antitoxin?MqsA?homolog?in?Pudomonas?fluorescens?2P24?has?a?rewired?regulatory?circuit?through?evolution.?Environ?Microbiol.?2019?
Zhao?JH,?Chen?JH,?Wang?Y,?Wang?ZP#,?He?YX#.?The?putative?compatible?solute-binding?protein?ProX?from?Mycobacterium?tuberculosis?H37Rv:?biochemical?characterization?and?crystallographic?data.?Acta?Crystallogr?F?Struct?Biol?Commun.?2018?Apr?1;74(Pt?4):231-235.
Yan?X,?Yang?R,?Zhao?RX,?Han?JT,?Jia?WJ,?Li?DY,?Wang?Y,?Zhang?N,?Wu?Y,?Zhang?LQ#,?He?YX#.?The?transcriptional?regulator?PhlH?modulates?2,4-diacetylphloroglucinol?biosynthesis?in?respon?to?the?biosynthetic?intermediate?and?end?product.?Appl?Environ?Microbiol.?2017?Aug?18
Li?L,?Zhu?Y,?Zhou?S,?An?X,?Zhang?Y,?Bai?Q,?He?YX#,?Liu?H#,?Yao?XJ#.?Experimental?and?Theoretical?Insights?into?the?Inhibition?Mechanism?of?Prion?Fibrillation?by?Resveratrol?and?its?Derivatives.?ACS?Chem?Neurosci.?2017?Aug?17
Sun?C,?Yan?K,?Han?JT,?Tao?L,?Lv?MH,?Shi?T,?He?YX,?Wierzba?M,?Tax?FE,?Li?J.Scanning?for?New?BRI1?Mutations?via?TILLING?Analysis.?Plant?Physiol.?2017?Jul;174(3):1881-1896.
Nan?Q,?Qian?D,?Niu?Y,?He?YX,?Tong?S,?Niu?Z,?Ma?J,?Yang?Y,?An?L,?Wan?D,?Xiang?Y.?Plant?Actin-depolymerizing?Factors?Posss?Opposing?Biochemical?Properties?Arising?From?Key?Amino?Acid?Changes?Throughout?Evolution.?Plant?Cell.?2017?Jan?25
Wu?D,?Tao?X,?Chen?ZP,?Han?JT,?Jia?WJ,?Zhu?N,?Li?X,?Wang?ZP#,?He?YX#.?The?environmental?endocrine?disruptor?p-nitrophenol?interacts?with?FKBP51,?a?positive?regulator?of?androgen?receptor?and?inhibits?androgen?receptor?signaling?in?human?cells.?J?Hazard?Mater.?2016?Apr?15;307:193-201
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